Meds and you

27 September 2013

Buspirone

Buspirone is an anxiolytic. Anxiolytics are drugs that are used to treat anxiety.

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Buspirone is the active ingredient of Buspar tablets (Nappi code: 783846-002) & Pasrin tablets (Nappi code: 825719-003).

General information
Buspirone is an anxiolytic. Anxiolytics are drugs that are used to treat anxiety.

In South Africa buspirone is registered for the treatment of generalised anxiety disorder with or without associated depression.

This medication does not cure the underlying cause of anxiety, but simply keeps the symptoms under control. For this medication to be effective it has to be taken regularly, even if you do not notice an immediate effect. The decision to stop using this medication should only be made by your doctor.

It should be noted that because this drug may cause dizziness, light-headedness and/or sedation, driving and any hazardous tasks should be avoided until you know how this medication affects you.

How does buspirone work?
Buspirone selectively affects the activity of a neurotransmitting chemical in the brain (serotonin) thereby affecting mood end emotional states. It has a lower potential for addiction and a lower sedative effect than most other drugs used to treat anxiety.

Fast facts

Drug schedule: schedule 5
Available as: buspirone is available as tablets
What does it do? Buspirone is used to reduce anxiety
Overdose risk: low
Dependence risk: low
Is buspirone available as a generic? yes
Is buspirone available on prescription only? yes

User information

Onset of effect: it may take several weeks before the optimal effect of this drug may be visible.
Duration of action: 8 hours
Stopping this medicine: do not stop using this medication abruptly as it may cause a recurrence of the original symptoms being treated. It is advised that you decrease your dose gradually as directed by your doctor.
Prolonged use: no problems are expected with long-term use.

Special precautions
Consult your doctor before using this drug if:

  • you have liver or kidney disease

  • you have a history of seizures

  • you are currently being, or in the last 14 days have been, treated with monoamine oxidase inhibitor antidepressants

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children under the age of 18 years.
The elderly: caution is advised in the elderly as side effects are more likely to occur.
Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
dizziness
X

X

headache
X

X

nausea
X

X

restlessness
X

X

light-headedness
X

X

nervousness
X

X

sedation

X
X

diarrhoea

X
X

dry mouth

X
X

urinary frequency

X
X

muscle cramps

X

X
palpitations

X

X
skin rash

X

X
seizures

X

X
blurred vision

X
X

Interactions Drug interactions

Alcohol increased sedation
Diltiazem, Verapamil ncreased risk of buspirone side effects
Erythromycin increased risk of buspirone side effects
Itraconazole increased risk of buspirone side effects
Ketoconazole increased risk of buspirone side effects
Diclofenac increased risk of buspirone side effects
Doxycycline increased risk of buspirone side effects
Carbamazepine decreased effect of buspirone
Nevirapine decreased effect of buspirone
Phenobarbital decreased effect of buspirone
Phenytoin decreased effect of buspirone
Monoamine Oxidase Inhibitor antidepressants increased risk of a dangerous rise in blood pressure
Nefazodone increased risk serotonin syndrome
Trazodone increased risk serotonin syndrome

Disease interactions
Consult your doctor before using this drug if you have liver or kidney disease or if you have a history of seizures.

Overdose action
Seek immediate emergency medical attention.

Recommended dosage
Adults, oral: 5 - 15 mg three times daily. The starting dose should be as low as possible, and the dose gradually increased until the desired effect is reached.

Interesting fact
Buspirone is sometimes used to treat premenstrual syndrome.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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