Meds and you

27 September 2013

Bumetanide and potassium

The combination of bumetanide and potassium is the active ingredient found in Burinex K (Nappi code: 711150-007, 71116-015, and 016).

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The combination of bumetanide and potassium is the active ingredient found in Burinex K (Nappi code: 711150-007, 71116-015, and 016).

General information

Bumetanide is a diuretic, a drug that increases the flow of urine from the body, prescribed for the treatment of oedema (water retention), (particularly where potassium supplementation is desired), that is associated with congestive heart failure (a condition resulting from weakness of the heart muscle, which causes the heart to lose its pumping ability. As a result fluid backs up in the lungs and may also accumulate in the legs) and liver or kidney disease. It is often prescribed for the treatment of high blood pressure.

Potassium is an electrolyte, which are chemicals such as salts and minerals needed for various functions in the body.

This combination should not be taken at night and the last dose should be taken at no later than 18:00 as this medication may cause loss of sleep as a result of frequent urination.

How does this combination work?

The combination of bumetanide and potassium increases the flow of urine from the body, while helping to control the body's fluid balance that may result from the use of this strong diuretic.

Fast facts

Drug schedule: schedule 3
Available as: the combination of bumetanide and potassium is available as tablets.
What does it do? The combination of bumetanide and potassium increases the flow of urine from the body.
Overdose risk: low
Dependence risk: low
Is this combination available as a generic? no
Is this combination available on prescription only? yes

User information

Onset of effect: within 30 minutes
Duration of action: up to 4 hours
Dietary advice: this combination should best be taken with or after a meal, and with plenty of water.
Stopping this medicine: do not discontinue this medication without consulting your doctor as symptoms may recur with premature stoppage.

Special precautions

Consult your doctor before using this drug if:

  • you have a bleeding disorder
  • you are taking ACE-inhibitor drugs
  • are allergic to sulphur-containing drugs
  • you have kidney or liver disease
  • you have a stomach ulcer
  • you have Addison’s disease
  • you have been diagnosed with an intestinal obstruction
  • if you are dehydrated
  • if you have a condition that makes urination difficult, such as prostate trouble
  • you have diabetes

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: this medication is safe for use.
Infants and children: this medication is not intended for use in children.
The elderly: caution is advised in the elderly as side effects are more likely to occur.
Driving and hazardous work: this medication should be avoided as it may cause dizziness.
Alcohol: avoid concomitant use of alcohol with this medication as it may increase risk of dehydration. Hangovers may be more severe.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
dizziness
X

X

headache
X

X

low blood pressure
X

X

muscle cramps

X
X

nausea

X
X

dry mouth

X
X

unusual tiredness/weakness

X

X
pain in joints

X

X
irregular heart beat

X

X
diarrhoea
X

X

abdominal discomfort
X

X

black stools

X

X
painful swallowing

X

X
palpitations

X

X
confusion

X

X
skin rash

X

X

Interactions

Drug interactions

non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen may reduce the drug's diuretic effect
aminoglycoside antibiotics may induce hearing damage
amphotericin B increased risk of low potassium levels
Digoxin increased risk of digoxin toxicity
Halofantrine increase risk of heart rhythm disturbance
Lithium increased risk of lithium toxicity
Probenecid reduce clearance of the drug
terfenadine (antihistamine) increase risk of heart rhythm disturbance
Pimozide increase risk of heart rhythm disturbance
ACE inhibitors risk of potassium toxicity
potassium-sparing diuretics including amiloride, triamterene and spirinolactone risk of potassium toxicity

Disease interactions

Consult your doctor before using this drug if you have a bleeding disorder, are allergic to sulphur-containing drugs, have kidney or liver disease, are dehydrated, have a condition that makes urination difficult, have diabetes, a stomach ulcer, or if you have gout.

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention. Symptoms may include dizziness, muscle cramps and mental confusion.

Recommended dosage

Adults, oral: 2 tablets daily as a single dose.

(This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.)

 
 

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