Meds and you

Updated 11 February 2013

Bumetanide

Bumetanide is a powerful diuretic prescribed for the treatment of oedema that is associated with congestive heart failure.

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Bumetanide is the active ingredient of Burinex.

Bumetanide is also one of multiple active ingredients found in Burinex (Bumetanide + potassium).

General Information

Bumetanide is a powerful diuretic (a drug that increases the flow of urine from the body) prescribed for the treatment of oedema (water retention) that is associated with congestive heart failure (a condition resulting from weakness of the heart muscle, which causes the heart to lose its pumping ability. As a result, fluid backs up in the lungs and may accumulate in the legs) and liver or kidney disease. It is often prescribed for the treatment of high blood pressure.

Budesonide should not be taken at night and the last dose should be taken no later than 18:00 as this medication may cause loss of sleep as a result of frequent urination.

How does bumetanide work?

Bumetanide lower the amount of excess salt and water in the body by increasing the flow of urine.

Fast facts

Drug schedule: Schedule 3

Available as: Tablets and injection

What does it do? It increases the flow of urine from the body

Overdose risk: Low

Dependence risk: Low

Available as a generic ? No

Available on prescription only ? Yes

User information

Onset of effect: Within 30 minutes

Duration of action: Up to 4 hours

Dietary advice: Bumetanide can cause a loss of potassium from the body. Supplement with foods rich in potassium, especially tomatoes and bananas

Stopping: Do not discontinue without consulting your doctor, as symptoms may recur with premature stoppage

Prolonged use: Long-term use may be associated with a loss of salt from the body, which may cause muscle cramps, weakness, etc. Your doctor may keep an eye on this.

Special precautions

Alert your doctor before using this drug if:

  • you have a bleeding disorder,
  • you are allergic to sulphur-containing drugs,
  • you have kidney or liver disease,
  • you are dehydrated,
  • you have a condition that makes urination difficult, like prostate trouble, or
  • you have diabetes.

Pregnancy: Avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: This medication is safe to use.

Infants and children: This medication is not intended for use in children.

Elderly: Dosage may need to be reduced.

Driving and hazardous work: This medication should be avoided as it may cause extreme sedation.

Alcohol: Avoid concomitant use with this medication as it may increase risk of dehydration. Hangovers may be more severe.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

Dizziness

x

x

Headache

x

x

Low blood pressure

x

x

Muscle cramps

x

x

Nausea

x

x

Dry mouth

x

x

Rash

x

x

Unusual tiredness/ weakness

x

x

Pain in joints

x

x

Irregular heart beat

x

x

Interactions

Drug interactions

Non-steroidal anti-inflammatory drugs (NSAID's) like ibuprofen

May reduce diuretic effect

Aminoglycoside antibiotics

May induce hearing damage

Amphotericin B

Increased risk of low potassium levels

Digoxin

Increased risk of digoxin toxicity

Halofantrine

Increase risk of heart rhythm disturbance

Lithium

Increased risk of lithium toxicity

Probenecid

Reduce clearance of the drug

Terfenadine (antihistamine)

Increase risk of heart rhythm disturbance

Pimozide

Increase risk of heart rhythm disturbance

Disease interactions

Consult your doctor before using this drug if you have a bleeding disorder, are allergic to sulphur-containing drugs, have kidney or liver disease, are dehydrated, have a condition that makes urination difficult, have diabetes, or if you have gout.

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention. Symptoms may include dizziness, muscle cramps and mental confusion.

Recommended dosage

Dose: 0.5-2mg/day

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.

 

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