Meds and you

27 September 2013

Amisulpride

Amisulpride is an antipsychotic drug. They are drugs that are used to reduce the intensity of, or eliminate certain psychotic illnesses and emotional conditions.

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Amisulpride is the active ingredient of Solian tablets (Nappi code: 892309-005, 892310-001).

General information

Amisulpride is an antipsychotic drug. Antipsychotic drugs are drugs that are used to reduce the intensity of, or eliminate certain psychotic illnesses and emotional conditions, including psychosis.

In South Africa amisulpride is registered for the treatment of depression acute and chronic schizophrenia. Amisulpiride shortens the time to recovery with these conditions and prevents relapses.

For this medication to be effective it has to be taken regularly, even if you do not notice an immediate effect. Treatment should not be stopped abruptly, especially if you have been taking this drug for a prolonged period of time. To prevent withdrawal and a return of symptoms you should decrease your dose gradually only as directed by your doctor.

Amisulpride does not cure the underlying condition, but simply keeps the symptoms under control.

Remember that this medication has been prescribed only for you. Do not share it with anybody else.

It should be noted that because this drug may cause dizziness, light-headedness and/or sedation, driving and any hazardous tasks should be avoided until you know how this medication affects you.

How does amisulpride work?

Amisulpride acts on chemical messengers in the brain. Imbalances of these may cause mental illness. Amisulpride works by preventing and correcting the chemical imbalances. 

Fast facts

Drug schedule: schedule 5

Available as: amisulpride is available as tablets.

What does it do? Amisulpride stabilises chemical messengers in the brain and thereby regulates mood and bahaviour.

Overdose risk: medium

Dependence risk: low

Is amisulpride available as a generic? no

Is amisulpride available on prescription only? yes

User information

Onset of effect: the full benefit of this medication may only be seen after a few weeks of treatment.

Duration of action: up to 24 hours

Stopping this medicine: do not stop using this medication abruptly, as it may cause a recurrence of the original symptoms being treated. It is advised that you decrease your dose gradually as directed by your doctor.

Prolonged use: prolonged use may, in rare cases, cause tardive dyskinesia, a condition with symptoms including involuntary movement of the tongue and face.

Special precautions

Consult your doctor before using this drug if:

  • if you have a liver or kidney disease
  • if you are pregnant or thinking of becoming pregnant
  • if you have been diagnosed with a cardiovascular disorder or any heart disease
  • if you have high blood pressure
  • if you have been diagnosed with a blood disorder
  • If you have been diagnosed with brain tumours or breast cancer
  • If you have porphyria
  • if you have been diagnosed with phaeochromocytoma
  • if you have a history of seizures or have been diagnosed with epilepsy
  • if you have Parkinson's disease
  • if you are taking other medication

 

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.

Porphyria: avoid. This medication may cause serious adverse effects. Consult your doctor before use.

Infants and children: this medication is not intended for use in children.

The elderly: caution is advised in the elderly as side effects are more likely to occur.

Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

 

 

Side effects Frequency   Consult your doctor  
  Common Rare Only if severe In all cases
drowsiness x   x  
dizziness x   x  
insomnia x   x  
libido changes x   x  
headache x   x  
weight gain x   x  
feeling shaky x   x  
feeling restless   x x  
menstrual irregularities   x x  
fever   x   x
stiffness   x x  
unusual movement of mouth, tongue or whole body   x   x
tremors   x   x
yellow tinge to skin/eyes   x   x
convulsions   x   x
breathing difficulties   x   x
skin rash   x   x

 

Interactions

Drug interactions

 

 

alcohol increased CNS depression including drowsiness
anaesthetics increased CNS depression including drowsiness
antidepressants increased CNS depression including drowsiness
antihistamines increased CNS depression including drowsiness
benzodiazapines increased CNS depression including drowsiness
fluoxetine increased risk of Parkinson's-like symptoms
lithium increased risk of Parkinson's-like symptoms
sucralfate reduced effect of amisulpride
antacids reduced effect of amisulpride

 

 

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage

Adults, oral: 50-400mg/day

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This material is not intended to substitute medical advice, but is for informational purposes only.

               Please consult a physician for specific treatment and recommendations.

 

 

 

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