Scientists say they've found a big reason why treatment for
chronic hepatitis C infection works better for white patients than
It's a tiny variation in a gene.
People with a certain gene variant are far more likely to
respond to treatment, and that variant is more common in people
with European ancestry than African-Americans, researchers report.
In fact, that probably explains about half the racial disparity
in treatment response, the scientists estimate in a study published
online Sunday by the journal Nature.
The work involved 1,137 patients who had a chronic infection
with the most common type of hepatitis C virus found in the United
States and Europe, one that is is less responsive to treatment than
other types. They were given standard drug treatment.
Analysis showed the treatment wiped out the virus in about 80
percent of study participants with the favorable genetic variant,
compared to only about 30 percent among those who lacked it.
African-Americans who had the gene variant showed a better
response rate than whites who didn't have it, indicating that the
gene is a better predictor than ethnicity, the researchers said.
Standard treatment for chronic hepatitis C takes months and has
such potential side effects as flu-like symptoms and depression. So
in deciding whether to treat, patients and doctors might be helped
by testing for the variant first, say the study authors, from Duke
University and elsewhere.
An estimated 170 million people around the world and perhaps 3.2
million people in the United States alone have a chronic hepatitis
C infection. That puts them at risk for developing liver cirrhosis
and cancer. The virus is spread by contact with infected blood,
such as from using inadequately sterilized needles.