Incontinence

Updated 19 March 2015

Darifenacin

Darifenacin is a medication prescribed for the treatment of an overactive bladder.

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Darifenacin is the active ingredient of Enablex.

General Information

Darifenacin is a medication prescribed for the treatment of an overactive bladder, ie: when you experience repeated, sudden urges to urinate immediately, urinate frequently - 8 or more times - in a 24-hour period, or if leaking or wetting occurs, you may have an overactive bladder.

Before taking this medication, tell your doctor if have trouble emptying your bladder, if you have a weak urine stream, or if you have any other pre-diagnosed medical conditions.

Avoid over-exertion and be sure to take plenty of fluids when exposed to hot weather. Darifenacin may affect your ability to sweat, which may cause you to be more susceptible to heat stroke.

How does darifenacin work?

Darifenacin decreases the urgency to urinate by blocking certain chemical receptors responsible for bladder muscle contractions.

Fast facts

Drug schedule: Schedule 3

Available as: Darifenacin is available as extended-release tablets.

What does it do? Darifenacin treats the symptoms of an overactive bladder.

Overdose risk: Medium

Dependence risk: Low

Is darifenacin available as a generic? No

Is darifenacin available on prescription only? Yes

User information

Dietary advice: This product can be taken with or without food; it should however be taken with a glass of water.

Stopping this medicine: Do not stop using this medication without speaking to your doctor.

Prolonged use: No problems are expected; your doctor may require periodic liver function tests.

Special precautions

Consult your doctor before using this drug if:

  • If you have liver or kidney disease
  • If you have difficulty urinating
  • if you have glaucoma
  • if a you have a blockage in your digestive tract
  • inflammatory bowel disease
  • a disease affecting your muscles
  • you are taking any other medication.

Pregnancy: Avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant

Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: Safety and efficacy of this medication has not been established for children.

Elderly: No special precautions need to be taken.

Driving and hazardous work: Caution is advised as use of this medication may affect your vision. Avoid such activities until you know how this medication affects you.

Alcohol: Avoid concomitant use of alcohol with this medication.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

Constipation

x

x

Dry Mouth

x

x

Headache

x

x

Dry eyes, blurred vision

x

x

Nausea, mild diarrhoea

x

x

Dizziness, weakness

x

x

Fever, sore throat, body aches

x

x

Hot, dry skin

x

x

Extreme thirst

x

x

Severe constipation and abdominal pain

x

x

Urinary retention

x

x

Difficulty breathing

x

x

Swelling of the face, lips, tongue, or throat

x

x

Skin rash

x

x

Interactions

Drug interactions

Certain antifungals or antibiotics

Increased risk if darifenacin side-effects

Flecainide

Increased risk of flecainide side effects

Nefazodone

Increased risk if darifenacin side-effects

Nelfinavir or ritonavir

Increased risk if darifenacin side-effects

Tricyclic Antidepressants

Increased risk if antidepressant side-effects

Thioridazine

Increased risk if thioridazine side-effects

Disease interactions

Consult your doctor before using this drug if you have liver disease, difficulty urinating, glaucoma, a blockage in your digestive tract, inflammatory bowel disease, or if you have a disease affecting your muscles.

Overdose action

An overdose of this medication can be serious. Seek immediate emergency medical attention. Symptoms may include constipation, urinary retention, abdominal pain or weakness.

Recommended dosage

7.5 - 15 mg once a day

Reviewed by Dr. Owen Wiese (March 2015)

 

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Ask the Expert

Incontinence Expert

Prenevin Govender completed his MBChB at the University of Cape Town in 2001. He obtained his Fellowship of the College of Urologists in 2009 and graduated with distinction for a Masters in Medicine from the University of Cape Town in 2010. His special interests include laparoscopic, pelvic organ prolapse and urinary incontinence surgery. He consults full-time at Life Kingsbury Hospital in Claremont.

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