Incontinence

29 March 2012

Botox works for overactive bladder

Allergan Inc said its Botox met the primary goals of a pair of late stage clinical trials for overactive bladder by significantly reducing episodes of urinary incontinence.

0

Allergan Inc said its Botox met the primary goals of a pair of late stage clinical trials for overactive bladder by significantly reducing episodes of urinary incontinence.

Based on the trial results, Allergan said it filed applications with US and European health regulators seeking the additional approval to treat adults suffering from overactive bladder who have not responded well to, or are intolerant of, anticholinergic drugs, such as Pfizer Inc's Detrol (tolterodine).

In both studies, Botox (onabotulinumtoxinA) led to a highly statistically significant decrease in the number of daily incontinence episodes compared with a placebo, the company said. The study involved patients whose condition was not caused by a neurological disorder.

Urinary tract infection common side effect

The study results were announced in conjunction with Allergan's Research and Development Technology review.

An estimated 3.2 million Americans with overactive bladder are taking oral anticholinergic drugs, Allergan said. It is believed that more than half of patients discontinue their medication due to inadequate response or intolerance to the drugs.

Treatment with Botox in the studies was well tolerated, with urinary tract infection among the most common side effects at a rate of 15% to 20% of patients, Allergan said.

(Reuters Health, March 2012) 

Read more:

Botox basics

Urinary tract infection

 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.

Ask the Expert

Incontinence Expert

Prenevin Govender completed his MBChB at the University of Cape Town in 2001. He obtained his Fellowship of the College of Urologists in 2009 and graduated with distinction for a Masters in Medicine from the University of Cape Town in 2010. His special interests include laparoscopic, pelvic organ prolapse and urinary incontinence surgery. He consults full-time at Life Kingsbury Hospital in Claremont.

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules