A new bird flu virus that has killed 13 people in China is
still evolving, making it hard for scientists to predict how dangerous it might
Influenza experts say the H7N9 strain is probably still
swapping genes with other strains, seeking to select ones that might make it
If it succeeds, the world could be facing the threat of a
deadly flu pandemic. But it may also fail and just fizzle out.
The virus' instability also raises questions about whether H7N9
might become resistant to antiviral drugs such as Roche's antiviral drug
Tamiflu, a possibility already suggested by analyses of genetic data available
on the strain so far.
"Even with just the three (gene) sequences we have available,
there's some evidence that one doesn't quite fit with the other two. So we might
think this virus is still fishing around for a genetic constellation that its
happy with," said Wendy Barclay, a flu virologist at Imperial College
"Maybe there are other viruses out there that it is still
exchanging genes with until it gets to a stable constellation."
To be able to say with any confidence whether this new strain,
which before March had never been seen in humans, could go on to cause a
pandemic, scientists need to know a lot more.
H7N9 A triple mix bird flu
So far, genetic sequence data from samples from three H7N9
victims and posted on the website of GISAID, the Global Initiative on Sharing
All Influenza Data, show the strain is a so-called "triple reassortant" virus
with a mixture of genes from three other flu strains found in birds in
Writing in the New England Journal of Medicine
researchers who conducted a detailed analysis of the strain's origin said it
seemed that so far the reassortment of genes to make H7N9 had taken place in
birds rather than in humans or in any other mammal - a somewhat reassuring
That study is available at Barclay said this may continue, and
could mean it is some time before the strain finds a form in which it can spread
swiftly and efficiently in bird populations.
Yet genetic analyses also show the virus has already acquired
some mutations that make it more likely be able to spread between mammals, and
more able to spark a human pandemic.
A study in the online journal Eurosurveillance by leading flu
experts Yoshihiro Kawaoka of the University of Wisconsin and Masato Tashiro at
the National Institute of Infectious Diseases in Tokyo, said the H7N9 sequences
"possess several characteristic features of mammalian influenza viruses, which
are likely to contribute to their ability to infect humans".
That sentiment was echoed by the World Health
Organization (WHO), which said "genetic changes seen among these H7N9 viruses
suggesting adaptation to mammals are of concern" and warned: "Further adaptation
While experts take some comfort in the lack of evidence so far
that H7N9 is passing from person to person - a factor that would dramatically
increase its pandemic potential - they are find little comfort in not yet
knowing how the 60 or so people confirmed as having this flu strain became
"We know H7 viruses can spill over into humans ... and for me
the most important thing to find out now is from which species do we think this
H7N9 is spilling over," said An Osterhaus, head of viroscience of the Erasmus
Medical Center in the Netherlands.
"Is it one species? Are there different species? At this stage
we are still lacking a lot of data."
He said rigorous surveillance of wild birds, such as ducks and
quail, and poultry such as chickens, as well as well-known flu-carrying mammals
such as pigs, should yield answers.
Recent pandemic viruses - including the H1N1 "swine flu" of
2009/2010 - have been mammal and bird flu mixtures. Experts say these hybrids
are more likely to be milder, because mammalian flu tends to make humans less
severely ill than bird flu.
Pure bird flu strains - like the new H7N9 strain and like the
H5N1 strain that has killed around 371 of 622 the people it has infected since
2003 - are generally more deadly for people.
The world's worst known pandemic, the "Spanish flu" of 1918
that killed more than 50 million people, was a bird flu that had picked up gene
mutations that enabled it to spread efficiently in humans.
David Heyman, a flu expert and head of Britain's Chatham House
Center on Global Health Security, said it is important to put the discovery of
H7N9 in humans into the context of modern-day scientific capability.
He said that in the years since the outbreak of Severe Acute
Respiratory Syndrome (SARS) in China in 2003, there has been a significantly
increased focus on detecting and reporting flu-like respiratory infections in
Asia and across the world.
The harder scientists look, he said, the more likely they are
to find viruses that are potentially threatening but may equally be the sort of
events that in the past might have flared up and petered out again under the flu
That said, he stressed this is no time to relax."Influenza
viruses are very unstable. And (any) mutation is a random event - so nobody can
predict when it will happen," he said. "You can't take your eye off anything.
You have to keep your eye on everything."