17 January 2013

Flu vaccine not linked to foetal death

Getting the flu vaccine while pregnant does not increase the odds of foetal death, according to a large study from Norway.


Getting the flu vaccine while pregnant does not increase the odds of foetal death, according to a large study from Norway.

Although foetal deaths were rare during the study, they were more common in pregnant women with the flu.

"Vaccination itself was not associated with increased foetal mortality and may have reduced the risk of influenza-related death during the pandemic" of 2009, said the team, led by Dr Siri Haberg of the Norwegian Institute of Public Health in Oslo.

Dr Jon Abramson of the Wake Forest Baptist Medical Center in North Carolina, who was not connected with the research, said it was already known that influenza can be unusually dangerous in pregnant women.

"The increased hospitalisation rate is about fourfold higher among pregnant women compared to women of a similar age who are not pregnant," he said.

With some exceptions, the US Centers for Disease Control and Prevention (CDC) recommends the flu shot for everyone over six months of age, including pregnant women.

The study, which appeared online today in the New England Journal of Medicine, encompassed the H1N1 pandemic in the fall and early winter of 2009 and took place after publicity about more than 30 cases of foetal death following vaccination.

Until then, pregnant women in Norway were not routinely advised to get the flu vaccine. During the pandemic, as much as 30% of the Norwegian population fell ill with the flu.

The vaccine was offered beginning on Oct. 19, 2009 and was usually given during the second and third trimester.

What the study found

The vaccine wasn't foolproof, but it cut a woman's risk of influenza by 70%.

Among nearly 26 000 women vaccinated during pregnancy - usually during the second or third trimester - there were 78 foetal deaths, or three per 1 000 pregnancies. Among about 87 000 pregnant women who were not vaccinated, there were 414 foetal deaths, or close to five per 1 000 pregnancies.

When the researchers focused on the women who developed the flu, the risk of losing their child to miscarriage or stillbirth was almost double that of those who had not been vaccinated.

Among all women, vaccination during the study period reduced the likelihood of foetal death by 12%, but that difference was not statistically significant, the researchers said.

They saw no evidence that vaccination increased the risk of premature delivery or having a baby with a low birth weight.

"We found no evidence that influenza vaccination of pregnant women increased the risk of foetal death," the researchers said. "However, influenza infection itself posed a major risk; among pregnant women who received a clinical diagnosis of influenza, the risk of foetal death nearly doubled."

Smaller studies in Canada and Denmark have produced similar results.

"Because of all these mounting pieces of evidence about the effect of influenza on pregnant women, the World Health Organization in the last year actually recommended that the number one priority for getting the flu vaccine is pregnant women, pandemic or not," Dr Abramson said.

(Reuters Health, January 2013)

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