Erectile dysfunction

Updated 08 March 2017

Topical cream for ED promising

A topical cream for erectile dysfunction shows promise in animal testing and could become an alternative for men who can't tolerate the pill form of the drugs, US researchers report.

0

Oral erectile dysfunction (ED) drugs, which belong to a class of medications called phosphodiesterase 5 (PDE5) inhibitors, are widely used and highly effective but can cause such side effects as headache, upset stomach, nasal congestion, facial flushing and hearing and vision problems.

Men who've recently had a heart attack or have severe heart disease have to use oral ED drugs with caution, if at all.

The new cream consists of nanoparticles that can carry drugs or other substances, such as nitric oxide, and deliver them in a controlled and sustained manner, according to the researchers, who are from Albert Einstein College of Medicine at Yeshiva University in New York City. Nitric oxide is the signalling molecule that dilates blood vessels responsible for creating an erection.

How the study was done
The nanoparticle therapy was tested on 18 rats bred to have age-related ED. Some rats received nanoparticles with nitric oxide, others received nanoparticles with nitric oxide plus an experimental ED drug called silorphin (which has a different mechanism of action than PDE5 inhibitors) and a third group of rats received nanoparticles with nitric oxide and the PDE5 inhibitor tadalafil (Cialis).

Five of seven of the rats that received nanoparticles with nitric oxide, and all 11 rats that received nanoparticles with nitric oxide and either silorphin or tadalafil showed significant improvements in erectile function.

"The response time to the nanoparticles was very short, just a few minutes, which is basically what people want in an ED medication," said study co-author Dr Joel M. Friedman, a professor of physiology, biophysics and medicine.

"In both rats and humans, it can take 30 minutes to one hour for oral ED medications to take effect." The study appears in the Journal of Sexual Medicine.

If safety and dosing studies in rats are successful, human trials of the nanoparticle therapy could begin within a few years, the researchers said. – (HealthDay News, September 2009)

Read more:
Erectile dysfunction in teens
ED drug no PTSD help

 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.

Ask the Expert

Erectile Dysfunction Expert

Dr Kenny du Toit is a urologist practicing in Rondebosch, Cape Town. He is also consultant at Tygerberg hospital, where he is a senior lecturer at Stellenbosch University. He is a member of the South African Urological Association, Colleges of Medicine South Africa and Société Internationale d’Urologie. Board registered with both the HPCSA (Health professions council of South Africa) and GMC (General medical council UK). He has a keen interest in oncology, kidney stones and erectile dysfunction.http://www.dutoiturology.co.za

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules