Drug therapy for premature ejaculation

Antidepressants
There have been reports in the urology literature of successful treatment of PE through the use of low dose antidepressants including Anafranil, Nuzak and Zoloft. One of the known side effects of these medications when used for depression is significantly delayed ejaculation. In the studies, extremely low doses of the antidepressant medication have prolonged ejaculation by at least 5 – 10 minutes. The medication is given approximately four hours before intercourse and will result in a significant delay of ejaculation.

Some patients have described side effects (drowsiness or nausea) with this treatment.

Self – injection therapy
Recently doctors have reported significant success using self – injection therapy. Essentially this approach is a self–paced therapy and medication, which over a period of six to twelve weeks will allow one to gain control of the erection rather than the other way around. Within 5 – 10 minutes of administering the medicine to the side of the penis, a full erection will develop that will last even after ejaculation. This means that even if one ejaculates prematurely, the erection will remain firm so making love can continue.

The rationale behind this approach is that it will enable extended penile contact with the vagina thereby “desensitising” the penis.