There's more evidence that routine colonoscopy confers life-extending
A new study that included almost 1 100 patients found that those whose cancer
was spotted by colonoscopy tended to have an earlier stage of disease at the
time of their diagnosis, as well as better survival.
In contrast, patients whose colorectal cancer was not diagnosed through
colonoscopy were at higher risk of having more invasive tumours, as well as
cancers that had already spread to other areas of the body.
"The findings provide yet another compelling reason for asymptomatic,
average-risk individuals over the age of 50 to get screened by colonoscopy,"
said Dr David Carr-Locke, chief of the division of digestive diseases at Beth
Israel Medical Center in New York City. Carr-Locke was not involved in the
In the study, researchers led by Ramzi Amri, of Massachusetts General
Hospital and Harvard Medical School in Boston, looked at outcomes for nearly 1
100 patients treated for colon cancer. In 217 cases, the cancer had been spotted
in a screening colonoscopy.
Double the odds
At the time of their diagnosis, patients whose cancers had not been spotted
via colonoscopy had nearly double the odds of having an invasive tumour compared
to those whose tumour had been found through a colonoscopy. They also had more
than three times the odds for a metastatic tumour that had spread to other parts
of the body, the researchers reported.
During follow-up, patients not diagnosed through colonoscopy screening had
higher death rates, higher cancer recurrence rates, shorter survival and shorter
lengths of time during which they were cancer-free, the team found.
"Compliance to screening colonoscopy guidelines can play an important role in
prolonging longevity, improving quality of life, and reducing health care costs
through early detection of colon cancer," Amri and colleagues wrote.
Since they were introduced in 2000, colonoscopy guidelines recommended by the
US National Institutes of Health appear to have decreased overall rates of
colorectal cancer, the researchers said.
Dr Maurice Cerulli, programme director in the division of gastroenterology,
hepatology and nutrition at North Shore-LIJ Health System in New Hyde Park, NY,
agreed that the adoption of routine colonoscopy has "resulted in a decrease in
the number of people dying from colon cancer over the past decade".
The US National Cancer Institute has more about colorectal
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