Glucophage is often used for insulin resistance , or patients who are pre-diabetic. The main side effects are gastrointestinal, i.e. bloating, diarrhea, or cramping. These tend to be temporary, but if persisting, then the dose needs to be decreased or you can get a once a day slow release formulation. Regarding the tiredness, I don’t think that this is related to the Glucophage or the insulin resistance, and unfortunately I have too little other information to make a potential diagnosis
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