Posted by: Cheryl | 2011-11-30


Insulin Resistance

Is it advisable to try Antagolin before being tested for insulin resistance?
Thank you

Expert's Reply


Diabetes expert

Dear Cheryl

Insulin resistance is an area where there has been a lot of misinformation. To truly measure it one needs an infusion of insulin in one arm and glucose in another, in what is called an insulin clamp study.

In reality this is only done in a research setting. One can measure a fasting insulin and glucose level, and with a formula getting an estimate value, but in reality endocrinologists don’t do this as it doesn’t really provide us with good information.

The other point to make is that as one puts on weight, then you become more insulin resistant, as opposed to insulin resistance causing weight. Now with regards to antagolin, the medical company that makes it, currently has no evidence that I am aware of regarding its claims to improve insulin resistance or weight loss significantly.

To show weight loss, it would need to show that independent of lifestyle changes it can produce a minimum 5% weight loss in a large enough trial. I have emailed the company to ask them for these trials(there were none available on the site), and if they have reliable trials, then I will be able to feed back to you.

Dr Wayne May

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