Is it possible to "flush" away the build-up of dangerous substances in the brain that cause Alzheimer's disease?
That's what researchers from the University of Rochester (N.Y.) Medical Centre have tried on laboratory mice, and the results have indicated that the amyloid protein linked to causing Alzheimer's can be drained away.
According to a university news release, the "brain-drain" method doesn't address the cause of Alzheimer's, which most medical researchers believe is the build-up of a protein in the brain called amyloid-beta. This substance creates the lesions that interrupt a person's memory signals and eventually lead to irreversible dementia.
Helps the body regain control
So, rather than attack the cause of the protein, the researchers found a way to increase the body's ability to absorb amyloid-beta. This causes the brain to "order" levels of the substance in the brain to decline. This was done by using a modified form of soluble low-density lipoprotein receptor-related protein, which helps control the amount of amyloid-beta in the brain.
The result: The levels of amyloid-beta in the brains of the laboratory mice was reduced by 85 to 90 percent. The researchers are now working on adapting their procedure for clinical trial on humans.
The research paper was published online Sunday by the journal Nature Medicine. – (HealthDayNews)