Dementia

18 April 2007

Omega-3 may thwart dementia

A type of omega-3 fatty acid called docosahexaenoic acid (DHA) may help slow the growth of two kinds of brain lesions associated with Alzheimer's disease.

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A type of omega-3 fatty acid called docosahexaenoic acid (DHA) may help slow the growth of two kinds of brain lesions associated with Alzheimer's disease, a new study suggests.

The researchers at the University of California, Irvine, said their finding suggests that a diet rich in DHA - found in fish, eggs, organ meats, micro-algae, fortified foods and food supplements - may help prevent the development of Alzheimer's as people age.

In this study with genetically modified mice, the scientists found that DHA slowed accumulation of tau, a protein that leads to the development of neurofibrillary tangles, one of the two signature brain lesions of Alzheimer's.

The researchers also found that DHA reduced levels of the protein beta amyloid, which can clump in the brain and form plaques, another kind of lesion associated with Alzheimer's.

Simple changes may protect
"We are greatly excited by these results, which show us that simple changes in diet can positively alter the way the brain works and lead to protection from Alzheimer's disease pathology," study co-author Frank LaFerla, professor of neurobiology and behaviour, said in a prepared statement.

He and his colleagues also learned how DHA keeps beta amyloid in check. DHA reduces levels of presenilin, an enzyme that separates beta amyloid from its "parent," the amyloid precursor protein. Without presenilin, beta amyloid cannot be generated.

The study, published in the April 18 issue of The Journal of Neuroscience, adds to growing evidence that diet and lifestyle changes may help people lower their risk of developing Alzheimer's disease, the researchers said.

How to reduce your risk
"Combined with mental stimulation, exercise, other dietary intakes, and avoiding stress and smoking, we believe that people can significantly improve their odds against this disease," study lead author Kim Green said in a prepared statement.

The study was funded by Martek Biosciences Corp.

Alzheimer's is a neurodegenerative disease that strikes in about Five percent of people older than 65, and up to one-half of people by age 80. – (HealthDayNews)

Read more:
Alzheimer’s Centre
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April 2007

 

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