Dementia

02 February 2017

Can air pollution cause Alzheimer's?

Air pollution may cause more than just lung disease, as a new study finds that fine particles from air pollution may be to blame for about 20% of dementia cases.

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New research suggests that if tiny particles in the air from power plants and cars are inhaled, they might also invade the brain, increasing the risk for dementia.

Particle concentrators

"Although the link between air pollution and Alzheimer's disease is a new scientific frontier, we now have evidence that air pollution, like tobacco, is dangerous to the ageing brain," said study co-senior author Caleb Finch. He's with the University of Southern California's (USC) Leonard Davis School of Gerontology.

Read: Air pollution increases heart disease risk

For the study, the USC scientists collected samples of air particles with technology designed by university engineers. The researchers used the technology to expose female mice to air pollution.

"Our state-of-the-art aerosol technologies, called particle concentrators, essentially take the air of a typical urban area and convert it to the air of a freeway or a heavily polluted city like Beijing," study co-author Constantinos Sioutas, a professor of civil and environmental engineering, explained in a university news release.

"We then use these samples to test exposure and assess adverse neuro-developmental or neuro-degenerative health effects," he added.

The APOE4 gene

The mice carried a certain genetic variation, called the APOE4 gene, which increases the risk for Alzheimer's. After being exposed to air pollution for 15 weeks, the mice had 60 percent more amyloid plaque, the clusters of protein associated with the degenerative disease, the researchers said.

They also analysed data on more than 3,600 US women between the ages of 65 and 79 years from 48 states. None of the women had dementia when the study began.

After considering certain variables – such as race, ethnicity, lifestyle and health – the researchers found older women living in areas where minuscule air pollution particles exceed federal safety standards may be at 81 percent higher risk for cognitive decline. They may also face a 92 percent greater likelihood of developing dementia, including Alzheimer's disease.

The negative effects of air pollution on the brain were particularly notable among the women who the APOE4 gene, the study authors added.

The research was published in the journal Translational Psychiatry.

Read: Air pollution tied to anxiety in women

If their findings were extended to include the general population, the study's authors calculate that air pollution might be to blame for about 21 percent of all cases of dementia.

The research comes with several caveats. Firstly, it did not prove that air pollution causes the risk of dementia to rise. Secondly, studies involving animals frequently fail to produce similar results in humans.

Experimental data

Finch said: "Microscopic particles generated by fossil fuels get into our body directly through the nose into the brain. Cells in the brain treat these particles as invaders and react with inflammatory responses, which over the course of time, appear to exacerbate and promote Alzheimer's disease."

Read: Air pollution may lower IQ

Jiu-Chiuan Chen, co-senior author of the study, said, "Our study – the first of its kind conducted in the US – provides the inaugural scientific evidence of a critical Alzheimer's risk gene possibly interacting with air particles to accelerate brain ageing."

"The experimental data showed that exposure of mice to air particles collected on the edge of [the] USC damaged neurons in the hippocampus, the memory centre that is vulnerable to both brain ageing and Alzheimer's disease," added Chen, who is an associate professor of preventive medicine at USC's Keck School of Medicine.

Less than one-third of all US counties have ozone or particle pollution monitors, according to the American Lung Association. The group notes that six of the 10 most polluted US cities are in California. The USC researchers said the findings could have global implications because pollution has no borders.

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