Updated 03 August 2014

Chronic cough

A chronic cough is defined as one that lasts for longer than one month in individuals who do not respond to first-line treatment.



A chronic cough is defined as one that lasts for longer than two months. It is an extremely common complaint among the general population. In the South African context, if you have been coughing for more than two weeks with a fever or weight loss, it is important that you seek medical advice, as tuberculosis is a possible diagnosis and can be easily treated once the diagnosis is made.

Having a chronic cough can be very frustrating and is not always easily sorted out. However, with a thorough history, examination and systematic treatment approach, the cough can be effectively treated in the majority of cases.


The respiratory airways are lined with nerve fibers just under the surface of the airways. These nerve fibers are vital for keeping your airways clean. They can respond to changes in temperature, dust or other particles, acid and other irritants. There is considerable overlap in these complicated nerve pathways, thus making the diagnosis of the cause for a chronic cough particularly difficult in some cases.

The approach to sorting out the cause of a chronic cough is usually to look for the most common causes, exclude and/or treat these and then look for the more rare causes. Generally a “chronic cough” occurs by itself without other major symptoms such as fevers, weight loss or coughing of blood, etc. If any of these are present, your doctor will first consider alternative causes. 

The most common causes of a chronic cough are post-nasal drip, asthma, chronic obstructive airways disease or acid reflux. A smoker’s cough (early-morning with sputum) is not medically considered to be part of this syndrome. If you do have a “smoker’s cough”, it will usually resolve within a month after gibing up smoking. The most common causes are listed below. There are many other causes that could be considered if none of the more common causes are identified.

  • Upper airway cough syndrome/Chronic post-nasal drip. Mucus produced in the nose may either be swallowed or removed by clearing the throat during the day. At night mucus may pass through the vocal cords into the upper airways. This results in irritation and inflammation of the airways and a resultant cough. The post-nasal drip may be as a result of allergies, and treatment of the allergic response in the nose may resolve the problematic cough. Symptoms may be subtle and a trial of treatment is often instituted.
  • Asthma. A chronic cough may be the only symptom of asthma in some people and investigations for asthma should be done if this is suspected. Standard asthma treatment should solve the problem in this case. 
  • Chronic obstructive pulmonary disease (COPD). Smoking-induced airways disease (COPD/Emphysema frequently result in a cough, over and above the usual ‘smokers cough’). Stopping smoking and specific treatment for COPD will help reduce the cough.
  • Acid reflux. Symptoms of heartburn may be a pointer, but are not always present. Chemical irritation of the airways by acid also leads to the chronic cough. A special 24 hour pH monitoring test can be used to measure the acid levels in the oesophagus and relate these to the episodes of coughing. Treatment of the reflux with medication may be all that is required, but more extensive treatment can be employed if no response to medication is achieved and the acid reflux is confirmed to be the cause of the cough. 
  • Antihypertensive drugs (ACE inhibitors). Medication such as the ACE-inhibitors, a commonly used anti-hypertensive drug, has a particularly bad reputation for inducing a chronic cough. Replacement of this group of drugs with other forms of anti-hypertensives can stop a patient’s coughing.
  • Chronic inflammatory conditions such as tuberculosis or HIV-associated chronic pneumonias may also present with a chronic cough. In Third World countries these diseases are given a high priority and always have to be excluded in patients with respiratory symptoms. In developed countries these conditions may initially not be recognised as a cause of chronic cough.
  • Lung cancer may induce chronic cough due to the presence of a tumour in the airway. In smokers a bronchoscopy or CT scan may be required to exclude cancer as a cause of the cough.

Evaluation of patients

A very detailed medical history and physical examination will frequently suffice to determine the major factors that contribute to a chronic cough. The main purpose of this activity is to determine the trigger mechanisms. Unless these are eradicated, the treatment of the chronic cough will be unsuccessful. Frequently the associated symptoms and physical findings provide an answer as to the cause. In specific situations such as suspected asthma, cancer or acid reflux, further specialized tests may be needed. Examples include:

  • Lung Function Testing
  • Chest XR with or without a CT scan
  • Gastroscpy or Barium swallow


The success of treating patients with a chronic cough lies in the ability of the doctor to evaluate and eliminate the causative factors and does not rely on symptomatic relief measures such as cough suppressants. Most cough mixtures are ineffective in these situations.

Specific treatment of the underlying causes is indicated if any specific cause is identified. In situations where the possibility of post nasal-drip exists, but no clear signs are present, a trial of therapy is entirely appropriate. Sometimes two conditions may co-exist (asthma and post nasal drip), leading to the cough. Treatment of both conditions is thus indicated.

The process of investigation and treatment is often slow and frustrating for both the patient and the doctor. In addition to a lot of patience from both parties a thorough and systematic approach is required to get to the bottom of a chronic cough where the simple treatments have had no effect.

Written by Prof J.R. Joubert, MSc, MBChB (Stell), FCP (SA), MMed (Int. Med), MD (Stell)

Revised by Richard van Zyl-Smit, MBCHB, MRCP(UK), DIP HIV Man (SA), FCP(SA) Cert Pulm (SA), Specialist Physician and Pulmonologist, Division of Pulmonology and UCT Lung Institute, Department of Medicine, University of Cape Town, (October 2010)


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Professor Keertan Dheda has received several prestigious awards including the 2014 Oppenheimer Award, and has published over 160 peer-reviewed papers and holds 3 patents related to new TB diagnostic or infection control technologies. He serves on the editorial board of the journals PLoS One, the International Journal of Tuberculosis and Lung Disease, American Journal of Respiratory and Critical Medicine, Lancet Respiratory Diseases and Nature Scientific Reports, amongst others. Read his full biography at the University of Cape Town Lung Institute.

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