Childhood Diseases

Updated 08 April 2016

Bacteria may cause infant death

Researchers say they may have found that bacteria is a contributing factor in sudden infant death syndrome, one of the leading causes of death for children under one.

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A baffling phenomenon known as sudden infant death syndrome is one of the leading causes of death for children under one. Now, British researchers say they may have found a contributing factor: bacteria.

They found potentially dangerous bacteria such as Staphylococcus aureus and E. coli in nearly half of all babies who died suddenly and without explanation over a decade at a London hospital. Their findings are in the Lancet medical journal.

"This may be another piece to the puzzle," said Marian Willinger, a Sudden Infant Death Syndrome (Sids) expert at the US National Institute of Child Health and Human Development who was not connected to the British study.

The researchers cautioned, however, that while the bacteria were found in the Sids babies, that does not necessarily mean the bugs were responsible. Bacterial infections have long been suspected by some doctors to play a role in Sids.

Unclear if bacteria is cause or risk factor
"We don't know whether it's a cause or if it's identifying another potential risk factor," said Dr Nigel Klein, a professor at the Great Ormond Street Hospital for Children, where the study was conducted, and one of the paper's authors.

He said that the higher level of bacteria might be evidence of another condition that killed the baby, such as a room that was too hot or had poor ventilation. Or it may have been coincidental.

A Sids diagnosis means that no other cause of death can be found in an otherwise healthy infant who dies suddenly, usually in their sleep.

How the study was done
The researchers used autopsy samples from 470 infants who died suddenly and unexpectedly between 1996 and 2005. They found dangerous bacteria in 181 babies, or nearly half of the 365 whose deaths were unexplained. There were similar bacteria in about a quarter (14 of 53) of the babies who died of known causes, excluding those who died of bacterial infections.

Most of the bacteria were detected in the babies' lungs and spleens. At birth, mothers transfer some of their antibodies against infection to their babies. But when babies are from eight to 10 weeks old, the maternal antibodies have nearly run out and the babies typically have not started producing enough of their own.

That could make them particularly vulnerable to bacterial infections, said James Morris, a pathologist at the Royal Infirmary in Lancaster, who co-authored an accompanying commentary in the journal.

Sids typically strikes when babies are between 8 and 10 weeks old.

"The study is a good indicator that certain bacteria might be involved in causing sudden infant deaths," he said.

Willinger suggested that bacterial infections in infants might simply aggravate other risk factors for Sids, such as smoke exposure or babies sleeping on their stomachs.

"The bacteria in combination with other co-factors might push these babies over the edge," she said.

Recommendations for preventing Sids include putting babies to sleep on their backs and avoiding putting too many blankets on them. The study was paid for by the Foundation for the Study of Infant Deaths, a British charity. – (Sapa, May 2008)

Read more:
More clues to smoking-SIDS link

 

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Paediatrician

Prof Eugene Weinberg worked in the Paediatrics Department of the Red Cross Children’s Hospital for many years. He is presently a paediatric allergist at the Allergy Diagnostic Unit of the UCT Lung Institute in Mowbray.

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