Large doses of intravenous vitamin
C have the potential to boost chemotherapy's
ability to kill cancer
cells, according to new laboratory research involving human cells and mice.
Vitamin C delivered directly to human and mouse ovarian
cancer cells helped kill off those cells while leaving normal cells
unharmed, University of Kansas researchers report.
"In cell tissue and animal models of cancer, we saw when you add IV
vitamin C it seems to augment the killing effect of chemotherapy drugs on
cancer cells," said study co-author Dr Jeanne Drisko, director of
integrative medicine at the University of Kansas Medical Centre.
In follow-up human trials, a handful of cervical cancer patients given
intravenous vitamin C along with their chemotherapy reported fewer toxic side
effects from their cancer treatment, according to the study published in the
issue of Science Translational Medicine.
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Integrative medical therapy
"In those patients we didn't see any ill effects and we noticed they
had fewer effects from the chemotherapy," Drisko said. "It seemed to
be protecting the healthy cells while killing the cancer cells."
Intravenous vitamin C has been considered an integrative medical therapy for
cancer since the 1970s, Drisko noted.
But vitamin C's cancer-killing potential hasn't been taken seriously by
mainstream medicine ever since clinical trials performed by the Mayo Clinic
with oral vitamin C in the late 1970s and early 1980s found no anti-cancer
effects, she explained.
Researchers have since argued that those trials were flawed because vitamin
C taken orally is absorbed by the gut and excreted by the kidneys before its
levels can build up in the bloodstream.
But it's been hard to attract funding for further research. There's no
reason for pharmaceutical companies to fund vitamin C research, and federal
officials have been uninterested in plowing research dollars into the effort
since the Mayo research was published, Drisko said.
This latest investigation began with researchers exposing human ovarian
cancer cells to vitamin C in the lab. They found that the cells suffered DNA
damage and died off, while normal cells were left unharmed.
The researchers then tested vitamin C on mice with induced ovarian cancer.
The vitamin appeared to help chemotherapy drugs either inhibit the growth of tumours
or help shrink them.
Finally, the team conducted a pilot phase clinical trial involving 27
patients with stage III or stage IV ovarian cancer.
The patients who received intravenous vitamin C along with their
chemotherapy reported less toxicity of the brain, bone marrow and major organs,
the investigators found.
These patients also appeared to add nearly 8 75 months to the time before
their disease relapsed and progressed, compared with people who only received
chemotherapy. The researchers did note that the study was not designed to test
the statistical significance of that finding.
Vitamin C in the bloodstream helps kill cancer cells because it chemically
converts into hydrogen
peroxide when it interacts with tumours, Drisko said.
"If you can get your blood levels of vitamin C very high, it gets
driven into the space around the cancer cells," she explained. "In
that space, it's converted into hydrogen peroxide. It's very similar to what
our white blood cells do. They create hydrogen peroxide to fight infection."
Dr Stephanie Bernik, chief of surgical oncology at Lenox Hill Hospital in
New York City, said intravenous vitamin C therapy is not unheard of among
"I've had patients come in and say they were doing vitamin C
intravenous therapy," Bernik said. "I always tell them we don't know
enough to know whether it is good or bad."
This new research raises interesting possibilities, but until larger
clinical trials are conducted Bernik says her advice to patients will not
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