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In the current issue of Cancer Research, the investigators also describe the mechanism that may be responsible for this protection. Specifically, caffeine triggers a process by which skin cells containing irradiation-damaged DNA are removed. Thus, these defective skin cells can not reproduce and become cancerous.
"The results of the present study," senior investigator, Dr Allan H. Conney told
Reuters Health, "provide a possible mechanism for earlier observations indicating that oral administration of caffeine inhibits ultraviolet light-induced skin cancer in mice."
Conney of Rutgers, The State University of New Jersey, in Piscataway and colleagues supplied animals with caffeine in their drinking water for 1 to 2 weeks before UVB exposure.
The caffeine concentration led to blood levels comparable to that achieved in humans after 3 to 5 cups of coffee per day.
The team also determined that caffeine applied in a cream or gel directly to the skin immediately after UVB radiation exposure caused the death of DNA-damaged skin cells as well.
"We believe that these results will extrapolate to humans," continued Conney, "but clinical studies need to be done." He pointed out that previous "studies indicate that coffee or tea drinkers have a lower risk of non-melanoma skin cancer." - (Reuters Health)
SOURCE: Cancer Research, April 1, 2008.
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