Breast cancer

22 February 2016

Obesity linked to two types of cancer

People with excess weight may have more of a potentially tumour-promoting substance, scientists say.

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Researchers believe they've unlocked at least one way that obesity may promote the progression of pancreatic and breast cancers.

More than half overweight or obese

The finding could eventually lead to preventive treatments for those cancers, and maybe other cancers as well, the researchers said.

"The fact that this new mechanism underlies obesity's impact on two types of cancer suggests that it may be a common mechanism of tumour induction that could apply to other cancer types," said study co-senior author Rakesh Jain. Director of the Laboratory of Tumour Biology at Massachusetts General Hospital in Boston, Jain made his comments in a hospital news release. 

Read: What is breast cancer?

More than half of people diagnosed with breast and pancreatic cancers are overweight or obese, the researchers said. Previous studies have linked obesity with an increased risk of death from these and other types of cancer, they added.

However, the reason for the link between obesity and pancreatic and breast cancer was unclear.

In animal and laboratory experiments with cells and patient tumour samples, the researchers identified an association between obesity and high levels of a protein called placental growth factor (PlGF). 

Read: Symptoms of breast cancer

They also found that PlGF's binding to its receptor VEGFR-1 promotes tumour progression. VEGFR-1 affects the activity of immune cells within tumours, the study authors said.

The findings suggest that targeting the PlGF/VEGFR-1 pathway might be a way to prevent cancer in obese patients, the researchers said.

Prevention of tumour progression

However, it's important to note that research in laboratories and with animals doesn't always produce similar results in humans.

"We found that obesity increased infiltration of tumour-promoting immune cells and the growth and metastasis [spread] of pancreatic cancers," said study co-senior author Dr Dai Fukumura.

Read: Risk factors for breast cancer

He's also with the Laboratory of Tumour Biology as well as the department of radiation oncology at Massachusetts General Hospital.

When the researchers blocked VEGFR-1, they saw a shift toward prevention of tumour progression in obese mice for both pancreatic and breast cancer models. But, they didn't see the same prevention in lean mice, Fukumura said.

"We also found that PlGF was present in excess in obesity and that reduction of PlGF produced similar results to VEGFR-1 inhibition in the tumours of obese mice," Fukumura added.

The study was published online recently in the journal Clinical Cancer Research

Read more:

Obesity May Up Death Risk in Older Women With Colon Cancer

Breast cancer - the facts 

Obese women face breast cancer risk

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Breast cancer expert

Dr Gudgeon qualified in Birmingham, England, in 1968. She has more than 40 years experience in oncology, and in 1994 she founded her practice, Cape Breast Care, where she treats benign and malignant breast cancers. Dr Boeddinghaus obtained her qualification at UCT Medical School in 1994 and her MRCP in London in 1998. She has worked extensively in the field of oncology and has a special interest in the hormonal management of breast cancer. She now works with Dr Gudgeon at Cape Breast Care. Read more.

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