Breast cancer

22 September 2010

Gene Study Adds to Research of Breast Cancer Risk

Findings may help scientists develop way to predict individual risk in BRCA1 mutation carriers


This article has not necessarily been edited by Health24.

SUNDAY, Sept. 19 (HealthDay News) -- Newly identified gene mutations may affect breast cancer risk in some women, an international team of researchers has found.

It is already known that BRCA1 gene mutations substantially increase the risk of breast and ovarian cancer. This new study looked at whether other gene mutations might modify or alter that breast cancer risk.

The Mayo Clinic-led team first studied genetic mutations in 1,193 women with BRCA1 mutations who had invasive breast cancer and 1,190 women with BRCA1 mutations who didn't have breast cancer. They then used those findings to study a larger sample of women in each group.

The investigators eventually identified five gene mutations in the region of chromosome 19p13 that modify breast cancer risk in women with BRCA1 gene mutations. But these mutations do not affect ovarian cancer risk in these women, the researchers noted.

The findings, published in the current issue of the journal Nature Genetics, may help improve understanding of the causes of breast cancer and "should be useful in helping determine individual risk for breast cancer in BRCA1 carriers," senior author Fergus Couch said in a news release from the Mayo Clinic.

More information

The American Cancer Society has more about breast cancer.

(Copyright © 2010 HealthDay. All rights reserved.)


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Dr Gudgeon qualified in Birmingham, England, in 1968. She has more than 40 years experience in oncology, and in 1994 she founded her practice, Cape Breast Care, where she treats benign and malignant breast cancers. Dr Boeddinghaus obtained her qualification at UCT Medical School in 1994 and her MRCP in London in 1998. She has worked extensively in the field of oncology and has a special interest in the hormonal management of breast cancer. She now works with Dr Gudgeon at Cape Breast Care. Read more.

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