Breast cancer

05 May 2010

Aggressive Action Urged When Evaluating Breast Lesions

Suspicious growths in high-risk patients should be classified as soon as possible, researchers say


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MONDAY, May 3 (HealthDay News) -- Doctors should aggressively evaluate indeterminate breast lesions found in women with a high risk of breast cancer, the results of a new study suggest.

An indeterminate breast lesion is one that cannot be definitively classified as malignant or benign. High-risk women include those who have breast cancer, a history of breast cancer or a genetic predisposition for the disease, according to background information in a news release about the study.

"A short-term follow-up MRI, ultrasound and/or mammographic investigation is usually recommended for indeterminate lesions found in high-risk women. However, that may not be soon enough," study lead author Dr. Martin Korzeniowski, of McMaster University in Hamilton, Canada, said in the release.

He and his colleagues looked at 59 breast lesions in 55 women that were identified on MRI as indeterminate. Of those lesions, 22 percent turned out to be malignant on follow-up and subsequent biopsy.

"In our study, the cancer yield was substantial for indeterminate lesions identified on initial contrast-enhanced breast MRI, which suggests that those lesions should be evaluated more aggressively to exclude malignancy and increase one's chances for survival," Korzeniowski said.

The study was scheduled to be presented May 3 at the annual meeting of the American College of Radiology/American Roentgen Ray Society, held in San Diego.

More information

The American Cancer Society has more about breast cancer.


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Dr Gudgeon qualified in Birmingham, England, in 1968. She has more than 40 years experience in oncology, and in 1994 she founded her practice, Cape Breast Care, where she treats benign and malignant breast cancers. Dr Boeddinghaus obtained her qualification at UCT Medical School in 1994 and her MRCP in London in 1998. She has worked extensively in the field of oncology and has a special interest in the hormonal management of breast cancer. She now works with Dr Gudgeon at Cape Breast Care. Read more.

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