Angelina Jolie’s admission a few months ago that she had both
breasts removed in a double mastectomy, after testing positive for the breast
cancer gene, has put a spotlight on breast cancer prevalence.
Yet according to a local doctor, while the story has boosted
breast cancer awareness, it fails to point out that only 5% of women carry this
gene – leaving 95% of women who don’t carry it, but could still develop breast
Dr Owen Nosworthy, a Specialist Physician/Medical Oncologist
at Wits Donald Gordon Medical Centre says that Angelina’s case is “rare and
exceptional” as the gene responsible, BRCA1, is actually very rare and he
cautions against women rushing out to get tested.
“The genetic test for BRCA1 is not freely available and
requires that your doctor refers you to a specialist who will then take your
blood to get tested. The average woman is unlikely to test positive for it,
however, and I wouldn’t recommend that many women do this unless they have a
family history of breast cancer.
“The implications of the test are quite profound and women
who undergo it need counselling before they do so. The reason for this is that
if you do test positive for the gene, it has a major impact on your future,” he
Breast cancer in SA
While there are no figures on how many women have breast
cancer in South Africa, Dr Nosworthy says the numbers are ‘significant’ and
breast cancer is one of the most common cancers in South Africa.
the Cansa Foundation, one in 29 women in South Africa will be diagnosed with
breast cancer and one in 344 with ovarian cancer.
Nosworthy said double mastectomies were also uncommon
and preventative mastectomies were just as rare an occurrence. One of the
reasons for this is that medical schemes do not cover preventative
Another reason is that the BRCA1 gene, which is also
responsible for ovarian cancer, is actually only found in roughly 5% of women.
However, women who do not carry the gene are also at risk, especially if they
fall into one of the following risk categories:
- If you have a
strong family history of breast cancer, especially a mother or a sister who had
- If someone in your
family has tested positive for the gene.
- Older women who
have been on hormone replacement medication are at risk.
- Women who are
pregnant for the first time over the age of 35.
- Women who have
never had children.
What to do if you’re at risk?
So what happens if you find yourself in Angelina’s position?
You have a family member who had breast cancer (in this case it was her mother)
and you have tested positive for the BRCA1 gene. But you’re still young and
want to start a family - should you wait
to have a mastectomy?
“Young women who are aware of their risk and are carefully
monitored should still be able to go through a pregnancy provided they don’t
leave it too late. But the longer the breasts and ovaries remain in the body,
the greater the risk,” explains Dr Nosworthy.
In Angelina’s case
she chose to undergo the preventative double mastectomy, reducing her risk from
almost 90% down to 5%. But there is still a chance she could develop breast
cancer. And ovarian cancer, which is why at some point she will also have to
have her ovaries removed by means of a hysterectomy.
“Angelina will still
have to go for regular check-ups, and until she has her ovaries removed she is
still at significant risk for ovarian cancer too. This is why we say that if
you get tested for the gene, you need to be counselled. The implications of the
test are profound, whether you test positive or not,” he says.
Yet even if you test negative, or if you have no family
history, Dr Nosworthy says the best you can do is regular self examinations.
He says your first mammogram need not be until you are 35 or
40, the reason for this being that younger breasts are very dense and this
makes them difficult to read on a mammogram.
“It’s worth noting that most lumps are not cancer, but you
need to make your doctor aware of them regardless. Self-monitoring and
examination is your best defence,” he says.
For a graphic on how to do a breast self-examination click