05 February 2010

US study links infections in womb to asthma

U.S. researchers have linked mothers' infection during pregnancy to asthma, the most common chronic disease among American children, in their offspring.


 This article has not necessarily been edited by Health24.

WASHINGTON (Reuters) - U.S. researchers have linked mothers' infection during pregnancy to asthma, the most common chronic disease among American children, in their offspring.

A 16-year study following nearly 400,000 births in California found that when mothers had an inflammation known as chorioamnionitis and if a baby was born pre-term, that child was more likely to develop asthma by age 8.

Such inflammation of the placenta or amniotic fluid can result from a number of bacterial infections of the vagina, including E. coli and group B streptococci.

Chorioamnionitis complicates 8 percent of pregnancies, according to the study published on Monday in the Archives of Pediatrics and Adolescent Medicine.

Dr. Darios Getahun of the Kaiser Permanente Department of Research & Evaluation in Pasadena, California, who led the study, said doctors had assumed that being born pre-term was the reason children developed asthma later in life.

The study showed that chorioamnionitis is a factor in asthma independent of pre-term birth, Getahun said in a telephone interview.

Getahun said the findings point out the importance of prenatal care.

"Women sometimes tend to underestimate the importance of prenatal care and miss opportunities for finding this type of problem before it occurs," he said.

In 2006, nearly 10 million U.S. children were diagnosed with asthma and 6.8 million had an asthmatic episode, making it the most common chronic childhood disease, according the U.S. Department of Health and Human Services.

The researchers used electronic health records to follow 397,852 single births from 1991 to 2007 at Kaiser Permanente medical centers in Southern California.

Blacks are about 25 percent more likely to have asthma than whites and this infection could explain much of the difference, the researchers said.

If a mother had the infection and if her baby was born pre-term, the risk of asthma was 98 percent higher for black children, 70 percent higher for Hispanic children and 66 percent higher for whites, the researchers found. .


Read Health24’s Comments Policy

Comment on this story
Comments have been closed for this article.

Ask the Expert

Asthma Expert

Professor Keertan Dheda has received of several prestigious awards including the 2014 Oppenheimer Award, and has published over 160 peer-reviewed papers and holds 3 patents related to new TB diagnostic or infection control technologies. He serves on the editorial board of the journals PLoS One, the International Journal of Tuberculosis and Lung Disease, American Journal of Respiratory and Critical Medicine, Lancet Respiratory Diseases and Nature Scientific Reports, amongst others.Read his full biography at the University of Cape Town Lung Institute

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules