01 June 2010

Obesity and asthma linked

A new study confirms a link between obesity and asthma.


A new study confirms a link between obesity and asthma.

A number of studies have shown an association between obesity and asthma, both of which have become much more common over the past three decades, Dr Jun Ma of the Palo Alto Medical Research Institute in California note in the medical journal Allergy.

Ma and her team looked at about 4,500 men and women from the National Health and Nutrition Examination Survey for 2005-2006. About a third were overweight, and another third were obese.

Of the group, 41% had some type of allergy, while 8% had asthma. The researchers wanted to tease out those rates because allergy and asthma are related in some people.

Asthma risk rises with BMI

As much as 12% of the obese individuals had asthma, compared to six percent of the normal-weight study participants. And the likelihood of asthma rose as the body mass index - BMI, a relation of weight and height used to gauge obesity - increased and waist circumferences expanded.

The risk of asthma was more than tripled for the most obese individuals compared to normal weight people.

Reason for link unknown

But the reason why the two might be related is still not clear. Some researchers have suggested the system-wide, low-grade inflammation that occurs with obesity may be a factor, while others have argued that resistance to the key blood-sugar-regulating hormone insulin - which rises with excess weight - is the reason for the link. That resistance often foretells the onset of diabetes.

37% were either diabetic or had insulin resistance. The study did not find any evidence, however, that insulin resistance was responsible for the relationship, and allergy was not related to either weight or insulin resistance.

The findings don't rule out the possibility that insulin may be a link between obesity and asthma, Ma told Reuters Health. There are a host of other potential reasons for the association, which seems complex, she added. - (Anne Harding/Reuters Health, June 2010)

SOURCE: Allergy, published online May 7, 2010.


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Professor Keertan Dheda has received of several prestigious awards including the 2014 Oppenheimer Award, and has published over 160 peer-reviewed papers and holds 3 patents related to new TB diagnostic or infection control technologies. He serves on the editorial board of the journals PLoS One, the International Journal of Tuberculosis and Lung Disease, American Journal of Respiratory and Critical Medicine, Lancet Respiratory Diseases and Nature Scientific Reports, amongst others.Read his full biography at the University of Cape Town Lung Institute

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