Arthritis

Updated 21 December 2015

Arthritis drug effective against parasites

A cheap off-patent drug that is commonly used for arthritis could be a wonder treatment for amoebic parasites that infect millions each year, 70 000 of them fatally, a study said.

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Researchers in California found that auranofin, an oral therapy for arthritis that has been around since 1985, is highly effective against the parasite Entamoeba histolytica.

Carried in water and food, the parasite is a major but often neglected hazard in poor countries, causing amoebic dysentery and liver abscesses.

Auranofin was found thanks to a hi-tech programme to screen potential drugs for "orphan" diseases.

Drug is safe

It was tested on parasites in a lab dish, then in mice with amoebic colitis and on hamsters with amoebic liver cysts, according to the study, published in the journal Nature Medicine.

The experiments suggest auranofin would be 10 times more effective than metronidazole, the current medication for amoebic infection, which means that it could be used in very small doses or even as a one-off tablet.

Better still, the drug has long been recognised as safe.

At recognised dosages, it has few side effects, whereas metronidazole can cause nausea, vomiting, dizziness and headaches.

"This is a drug that you can find in every country," said Anjan Debnath of the University of California at San Francisco in a press release.

Drug targets the enzyme

"Based on the dosage we're seeing in the lab, this treatment could be sold at about R20 per dose, or lower. That cost savings could make a big difference to the people who need it the most."

The discovery was made thanks in part to US federal funding to identify drugs which tackle a neglected, or "orphan," disease.

This definition applies to a disease with fewer than 200 000 cases in the United States or a drug which is effective but whose costs of development and marketing are unlikely to be recovered.

Auranofin works by targeting an enzyme that protects the parasite from oxygen, to which it is highly sensitive, the researchers said.


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Professor Asgar Ali Kalla completed his MBChB (Bachelor of Medicine and Bachelor of Surgery) degree in 1975 at the University of Cape Town and his FRCP in 2003 in London. Professor Ali Kalla is the Isaac Albow Chair of Rheumatology at the University of Cape Town and also the Head of Division of Rheumatology at Groote Schuur Hospital. He has participated in a number of clinical trials for rheumatology and is active in community outreach. Prof Ali Kalla is an expert in Arthritis for Health24.

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