Arthritis

Updated 22 March 2016

Paracetamol ineffective for arthritis pain

A new study found that acetaminophen (paracetamol/Tylenol/Panado) is not ideal for treating osteoarthritis pain and that nonsteroidal anti-inflammatory drugs (NSAIDs) are much more effective.

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Acetaminophen – commonly known as Tylenol in the United States (and paracetamol in South Africa) – isn't an effective choice for relieving osteoarthritis pain in the hip or knee, or for improving joint function, a new study finds.

Risk for heart disease and death

Although the drug rated slightly better than placebo in studies, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or diclofenac are better choices for short-term pain relief, the researchers said.

"Regardless of dose, the prescription drug diclofenac is the most effective drug among painkillers in terms of improving pain and function in osteoarthritis," said lead researcher Dr Sven Trelle. He's co-director of clinical trials at the University of Bern in Switzerland.

However, even diclofenac comes with side effects.

"If you are thinking of using a painkiller for osteoarthritis, you should consider diclofenac," Trelle said, but also keep in mind that like most NSAIDs the drug increases the risk for heart disease and death.

Read: Exercise and physical therapy improve arthritis symptoms

Tylenol manufacturer McNeil Consumer Healthcare took issue with the new study.

"We disagree with the authors' interpretation of this meta-analysis and believe acetaminophen remains an important pain relief option for millions of consumers, particularly those with certain conditions for which NSAIDs may not be appropriate including cardiovascular disease, gastrointestinal bleeding, and renal [kidney] disease," the company said in a prepared statement.

Leading cause of pain

"The safety and efficacy profile of acetaminophen is supported by more than 150 studies over the past 50 years," the company added.

The new report was published in The Lancet.

Osteoarthritis is the leading cause of pain in older people. It can impair physical activity, and that increases the risk of obesity, heart disease, diabetes and general poor health, the study authors said.

One expert said it's "not surprising" that acetaminophen won't help arthritis pain.

Read: Can yoga help to ease your arthritis pain?

"Osteoarthritis is caused by inflammation of the joints, and acetaminophen is not meant for inflammation," explained Dr Shaheda Quraishi, a physiatrist at Northwell Health Pain Center in Great Neck, New York.

The current research included information from 74 trials published between 1980 and 2015. These trials included more than 58,000 patients. The studies compared how well various doses of acetaminophen and seven different NSAIDs relieved arthritis pain.

Acetaminophen can also be dangerous

The researchers found that acetaminophen was slightly better than an inactive placebo. But they added that taken by itself, acetaminophen has no role in treating osteoarthritis, regardless of dose.

The maximum daily dose of diclofenac – a prescription pain reliever was the most effective treatment for pain and disability, the new study showed. The researchers also found diclofenac was better than the maximum doses of NSAIDs, including ibuprofen, naproxen (Aleve) and celecoxib (Celebrex).

In addition to not helping with pain, one expert pointed out that acetaminophen can also be dangerous.

Read: Alternative remedies for joint pain

"Acetaminophen may not be as safe as most people would believe: it is known to be toxic to the liver, and acetaminophen overdose is a leading cause of liver transplantation," said Dr Nicholas Moore. He's from the department of pharmacology at the University of Bordeaux in France. Moore is also the co-author of an accompanying journal editorial.

"NSAIDs are much more effective painkillers, and avoiding them puts patients at risk of overdosing with acetaminophen," he said.

New painkillers are needed, but "narcotics are not a good choice", Moore added. Prescription narcotic painkillers – drugs such as Oxycontin, Vicodin and Percocet are not as effective as NSAIDs for inflammatory pain, he explained. And the risk of dependency or overdose with narcotics is considerable, he added.

"We should look also at older drugs that may have been discarded, and perhaps work more to understand the mechanism of action of acetaminophen to develop a new, more effective and less toxic drug of the same class, or develop new classes of painkillers," Moore suggested. 

Read more: 

What is osteoarthritis? 

What is rheumatoid arthritis? 

Treatment of rheumatoid arthritis

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Professor Asgar Ali Kalla completed his MBChB (Bachelor of Medicine and Bachelor of Surgery) degree in 1975 at the University of Cape Town and his FRCP in 2003 in London. Professor Ali Kalla is the Isaac Albow Chair of Rheumatology at the University of Cape Town and also the Head of Division of Rheumatology at Groote Schuur Hospital. He has participated in a number of clinical trials for rheumatology and is active in community outreach. Prof Ali Kalla is an expert in Arthritis for Health24.

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