Your odds of having acne may depend on whether the "good" strain of a
particular type of bacteria lives on your skin, a new study suggests.
"People never think of wanting to have good bacteria on their skin," said
lead author Huiying Li, an assistant professor of molecular and medical
pharmacology at the University of California, Los Angeles. "But some of them you
should love." It's the presence of acne-defeating bacteria that allows people
without acne to live relatively pimple-free, she explained.
Li and her team studied the bacterial strains on people's faces using genomic
analysis of microbial DNA. They discovered that the bacteria responsible for
acne - called Propionibacterium acnes or P. acnes - are more
complex than previously understood.
When studied at the genomic level, bacteria with the same name were actually
representative of three different strains. People with acne tend to have one or
two of the strains associated with the condition, while those with healthy skin
have a good strain that seems to destroy offending bacteria.
So whether or not you develop acne may be tied to what strain of P.
acnes your skin carries.
The next step
The strain of P. acnes that is associated with healthy skin works
much like the way live bacteria in yoghurt help defend the intestines from
harmful bacteria, Li said.
"Our next step will be to explore whether a probiotic cream might block bad
bacteria from invading the skin, preventing pimples before they start," Li said.
She hopes to find a way to transplant the good strain of bacteria that is
plentiful on the faces of people with healthy skin to those with acne.
Acne is the most common skin condition in the United States, affecting 40 to
50 million people - primarily teens and young adults - but it can strike at any
age, according to the American Academy of Dermatology. Li said archaeological
records show the disease goes back to ancient Egypt, where Pharaohs used magic
and spells to try to treat the problem. Acne is typically treated with oral
medications such as antibiotics, and topical creams that can help reduce oil on
the skin and kill bacteria.
When Li and her team originally compared the bacteria on the faces of people
with and without acne, they couldn't find any differences in the amount of
P. acnes on the skin. So they next looked at whether differences
existed in the strains of bacteria present.
How the study was done
The study included 49 people with acne and 52 without the condition, and used
over-the-counter pore-cleansing strips to get a sample of the microbes in the
pores on top of their noses. The scientists wanted to get the sample from the
pores because they contain more bacteria than the skin does, Li explained.
Most of the participants - 59 females and 42 males, average age of 22 - had
not been treated for acne in the past or were not being treated when the samples
were collected. The researchers looked at the genetic variation in strains of
P. acnes to better understand the skin "micro-biome" - the combination
of microbes and genomes interacting in a given environment.
Two unique strains of P. acnes appeared in 20% of the people but
rarely in those without the condition, and a third strain of P. acnes
was found only rarely on the skin of those with acne.
Dr David Leffell, a professor of dermatology and surgery at the Yale School
of Medicine, said the research, while not entirely innovative, begins to create
the fact base for better understanding the skin micro-biome. "In general, this
is a hot topic," said Leffell, who was not involved with the new study.
He said the discovery could potentially lead to agents that are specifically
designed to normalise the bacterial population or eliminate strains identified
For her part, Li said she expects the research will ultimately lead to a
personalised medicine approach to acne treatment, with particular creams
formulated to match the specific strains on each person's skin. "Some people may
have a lot of bad strains and no good strains, so the strategy for them may be
to kill all the bad strains first and then apply the good ones," she said. For
those who have a combination of good and bad strains, the probiotics could be
designed to promote the good strains, she explained.
When it comes to acne, Li says it's ultimately the balance of strains that
may be the key to skin health.
Learn more about acne from the US National
Library of Medicine.
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