I am not aware of any studies proving that a weekend break in medication can cause Bipolar Disorder. The concern may come in if children are aware of any emotional differences within themselves. Some feel they are 'nicer' people either on or off their meds and want to maintain that, thereby being apprehensive of taking them or not depending on the situation.
The appetite is a common reason for not taking meds on weekends and an understandable one at that - parents generally don't want an underweight child.
I am assuming your decision to not medicate on the weekends has been made in conjunction with your prescribing doctor. If not, please discuss your concerns with him/her as he/she will have the best insight into your son;s general health and well being.
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