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They hope it may be possible to some day swab the mouths of smokers to predict who is developing lung cancer - saving painful and dangerous biopsies of the lung.
The process may also lead to tests that will predict other cancers, said Dr Li Mao, an expert in head, neck and lung cancer at the University of Texas M.D. Anderson Cancer Centre in Houston.
"Our study opens the door to enhancing our ability to predict who has higher probability of getting tobacco-related cancers," Mao said. "Not only lung cancer, but pancreatic, bladder and head and neck cancers, which also are associated with tobacco use."
Smoking is the leading cause of lung cancer, but only about 10 percent of smokers ever get it. It causes few symptoms until it is advanced, which means patients are rarely diagnosed or treated until it is too late for a cure.
How the study was done
Mao's team wanted to find a way to monitor patients taking a drug - the COX-2 inhibitor celecoxib, sold by Pfizer under the brand name Celebrex - in the hopes of preventing lung cancer.
They looked at two genes known to help prevent the development of cancer - p16 and FHIT. "There is substantial damage (to the two genes) long before there is cancer," Mao said.
Speaking to a meeting of the American Association for Cancer Research in San Diego, they said they looked for specific damage to these genes in both lung samples and mouth samples from 125 long-time smokers.
"We are talking about just a brushing inside of the cheek to get the same information we would from lung brushings obtained through bronchoscopy," said Dr Manisha Bhutani, who works with Mao.
Study could lead to further trials
The p16 gene was shut down via a process called methylation in the lungs of 23 percent of the volunteers, while FHIT was affected in 17 percent. In the mouth, p16 was silenced in 19 percent of the smokers and FHIT in 15 percent of them.
In 95 percent of those whose genes were affected, they were affected in both the mouth and the lung, Mao and Bhutani said. This would make an easier test for pre-lung cancer than having to access the lung, the researchers said.
This could be useful in monitoring for lung cancer and also looking to see if prevention measures might work.
"This could have strong implications for further lung cancer prevention trials," they wrote in a summary submitted to the conference. At least one other group is working on a saliva test for breast cancer, one that looks for a mutated version of the HER-2 protein linked to some breast cancers. – (Reuters Health)
April 2008
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