Updated 30 January 2014

Probiotic drops might ease colic

Italian researchers say that infants given probiotics during the first three months of life appear to have fewer bouts of colic, acid reflux and constipation.


Infants given probiotics during the first three months of life appear to have fewer bouts of colic, acid reflux and constipation, according to Italian researchers.

Colic – excessive crying that is unrelated to a medical problem – is the cause of as many as one in five visits to paediatricians, the researchers said. It is also a source of anxiety and stress for parents.

"In Europe, probiotics are widely used to treat colic," said the study's lead author, Dr Flavia Indrio, of the department of paediatrics at Aldo Moro University of Bari.

Probiotics are friendly, live bacteria that help maintain a natural balance of organisms in the intestines, Indrio said. To see if probiotics could prevent colic and other gastrointestinal distress, the researchers gave more than 500 newborns either probiotic drops or a placebo.

Read: Colic – the facts

Shorter crying spells

The results, which were published online in the journal JAMA Paediatrics, showed that, over three months, the babies who got the probiotics had significantly shorter crying spells and less stomach upset than the babies given the placebo.

"Parents need to be informed that probiotics possibly cure and prevent colic," Indrio said. "This is something I use routinely in my practice to treat colic."

However, although the treatment caused no apparent harm or side effects, Indrio said these findings need to be replicated before this becomes standard care in the United States. The study showed an association between probiotic use and decreased colic, but it did not prove a cause-and-effect relationship.

Most common gastrointestinal problems

Colic, acid reflux and constipation are the most common gastrointestinal problems infants suffer. They often result in hospitalizations, feeding changes, drugs and loss of working days for parents, the researchers said.

Normally, the intestines have about 400 types of probiotic bacteria that serve to reduce harmful bacteria and keep the digestive system healthy. One of the most common probiotic bacteria is Lactobacillus, which is found in yogurt and was the bacteria given to infants in this study.

Read: Is it a probiotic?

During the 90-day study, parents recorded the number of times their babies vomited or had a bowel movement or an episode of inconsolable crying (as well as its duration). Parents also reported how many times they saw their paediatrician.

Babies taking the probiotic had an average crying time of 38 minutes, compared with 71 minutes among the infants receiving the placebo, the researchers found.

In addition, kids on probiotics vomited about three times a day on average, while kids on placebo vomited almost five times a day. Those taking the probiotic had an average of about four bowel movements a day, compared with three and a half among those taking the placebo, the researchers found.

Moreover, probiotic use was associated with an average saving of $119 for each baby, the researchers said.

Caution advised

Dr William Muinos, co-director of the division of gastroenterology at Miami Children's Hospital in Florida, is cautious about using probiotics to prevent colic.

Read: The benefits of probiotics

"We don't normally treat babies with probiotics," Muinos said. Some babies might be at risk for having the bacteria get into the bloodstream and causing serious illness, he said.

If parents want to give their baby a probiotic, it should be done under the supervision of their paediatrician, Muinos said. "[It should] not be used as a preventive tool, but as a treatment for colic, reflux or constipation," he said.

Read more:

No evidence that probiotics soothe colic
Colic: a myth?
Research shows that probiotics may help colics

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