Thanks to commercials for erectile dysfunction drugs, men know to seek
medical attention for "erections lasting more than four hours," but a new study
suggests a blood disorder is the cause of many prolonged erections.
While the condition - formally known as priapism - is rare, researchers
report in The Journal of Urology that between 14% and 30% of cases that show up
in US emergency rooms are men with sickle-cell disease.
"I would say what the paper is telling us is that sickle-cell disease is
still responsible for the bulk of the visits for priapism," said Dr Gregory
Broderick, professor of urology at the Mayo Clinic in Jacksonville, Florida, who
was not involved in the study.
How the research was done
Sickle-cell disease is an inherited disorder that leads to red blood cells
containing an abnormal type of hemoglobin. The defective cells frequently take
on a sickle- or crescent-shape and can block small blood vessels, which can lead
to tissue damage or even stroke.
Especially dangerous for people with the sickle-cell trait is becoming
dehydrated, which thickens the blood and can provoke a potentially fatal
"sickle-cell crisis."Other complications of the condition are anaemia, jaundice,
gallstones, severe leg and arm pain, and spleen, liver and kidney damage.
Previous studies have linked priapism to sickle-cell disease, as well as to
illegal drug abuse and use of erectile dysfunction treatments.
To get a better idea of who is most likely to experience priapism, and why,
researchers led by the University of Montreal Health Center's Dr Florian
Roghmann analysed a database of US ER visits between 2006 and 2009.
They found that 32 462 men came to ERs with priapism during that period,
which works out to be less than one emergency visit per 100 000 US men.
Of those patients, about 13% ended up being admitted to the hospital. The
figures were not significantly different from the past, according to the
researchers, which suggests the problem is not becoming more common as the
About half the men were treated at urban teaching hospitals. And about 14% of
were reported to have sickle-cell disease, but that number was even higher -
about 31% - among patients younger than 18 years old. About 4% of the patients
said they had abused drugs.
The study did not assess how many of the men had used erectile dysfunction
drugs. Nor could the researchers tell from the data how many of the ER visits
were by the same patients.
But the high proportion of patients identified as having sickle-cell disease,
according to Broderick, suggests sickle-cell is the main driver of priapism.
"You're really talking about a demographic slice," said Broderick, who has
researched priapism but wasn't involved with the new study.
Sickle-cell disease is most common among people of African, especially West
The condition is not thought to cause priapism directly by clogging blood
vessels with damaged cells. Rather, it's believed that when the defective red
blood cells break, their contents in the bloodstream interfere with signalling
from the brain that regulates blood flow and tissue responses, according to
The study team also found that priapism is more common during the summer
months and in warmer climates. Broderick said that may be due to dehydration
among people with sickle-cell disease.
But he cautioned that the new study cannot say for certain what caused
priapism in these patients. So the researchers can't rule out other
Regardless of the cause, Broderick said that the condition can lead to
serious long-term complications if it's not treated quickly.
"It's a time-dependant emergency. The more time they've had the ischemic or
erect penis, the more likely they're going to have erectile dysfunction," he