Our expert says:
Valdoxan ( Agomelatine ) because it works within the Melatonin system of the brain, which is part of our natural sleep control mechanisms and sleep-wake cycle, tends to normalize sleep relatively early ( as well as not having the nausea and sexual side-effects of many other popular ADs ).
It is recommended that one take it at bedtime in all the authorities I have read. Maybe not as your head hits the pillow, but a little while before retiring.
Curiously, Melatonin, the target chemical, seems to work better when taken in the morning, But I haven't found good work on assessing the impact of doing so with these drugs like Valdoxan which work on Melatonin. It doesn't seem to have been reported as causing sleeplessness in itself - but its not a direct sedative as such, so its beneficial impact on sleep may take days to demonstrate itself.
Maybe try it, and let us know if you notice any increased benefits !
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