Our expert says:
It would be important to analysis the fertilization failure in more detail, as there are many other possibilities a part from sperm genetics. Problems with sperm binding, sperm penetration, nuclei de-condensation as well as genetic factors within the oocyte itself may all contribute to fertilization failure. However were there is a strong suspicion of some form of genetic sperm problem, it might be valuable to analysis sperm for DNA fragmentation (apoptosis). A high percentage of apoptosis would certainly allude to the possibility of sperm genetic factors, which can then be further probed. However the same may also apply to egg genetic factors which although seemingly looks normal could be the significant if carefully analysed. Finally it is probably of most relevance to consider changing your IVF program to an ICSI program (intracytoplasmic sperm injection) and to consider if the second program fails the option of PGD (pre-genetic diagnosis). In this situation the embryo is analysed for genetic abnormalities and this is certainly of greater relevance than the individual parts i.e. sperm and egg.
Answered by: Dr M.I. Cassim
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