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Question
Posted by: Splat | 2011-07-28

Neoral

What are the side effects of the dialy long term use of Neoral?

My Pug was diagnosed with PDE just over a year ago, she has Cytozar injections every 21 days. She was on cortizone but this caused Cussions desease. Now she is on neoral dialy. 1 capsule a day.

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Our expert says:
Expert ImageCyberVet

Hi Splat

The side effects of Cyclosporin are as follows: - anorexia, gingival hyperplasia, red and swollen ears, muscle weakness, muscle cramps, insulin resistance skin lesions or change of hair coat – all the changes are transient and resolve once treatment has stopped. Rare side effects also include nephrotoxicity and/or hepatoxicity.

The drug is usually combined with prednisolone and/or ketoconazole. Ketoconazole significantly lowers the dose of the cyclosporine needed to attain effective blood levels.

Kind Regards

Angus Campbell

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

2
Our users say:
Posted by: CyberVet | 2011-08-01

Hi Splat

The side effects of Cyclosporin are as follows: - anorexia, gingival hyperplasia, red and swollen ears, muscle weakness, muscle cramps, insulin resistance skin lesions or change of hair coat – all the changes are transient and resolve once treatment has stopped. Rare side effects also include nephrotoxicity and/or hepatoxicity.

The drug is usually combined with prednisolone and/or ketoconazole. Ketoconazole significantly lowers the dose of the cyclosporine needed to attain effective blood levels.

Kind Regards

Angus Campbell

Reply to CyberVet
Posted by: Chill | 2011-07-28

Neoral is an immunosuppressant, and so long-term use can lead to greater susceptibility to infections - this means you''d have to be a bit careful at any sign of illness, and don''t wait before you take action.

In humans, it can increase potassium levels, which means one would be wise to avoid foods high in this - not as applicable to dogs. Your vet may want to do a blood test to monitor kidney and liver function now and then.

Unfortunately long-term use also rather increases the risk of some types of cancer. This won''t be as prevalent in dogs as in humans, because they don''t live as long, but you could chat to your vet about this risk.

Do a Google on cyclosporine in dogs, or (different spelling) ciclosporine - there''s a lot of information out there that you will find interesting.

Reply to Chill

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