Our expert says:
Wine is pretty strong alcohol, and can be absorbed quickly, thus rapidly having the same potential problems as any other form of alcohol. Generally, alcohol and lithium are not major problems when combined, but alcohol alone can, especially in sensitive people, have these effects, which are worth taking as a warning to avoid alcohol.
Agomelatine ( ? Valdoxan ? ) is a VERY VERY new product --- I wasn't even aware that it was available in South Africa, as whichever comapny is marketing it hasnt had the courtesy to send me information about it.
There are some promising indications that it might be useful --- it works on the Melatonin system in different ways to other current antidepressants , and may have an absence of sexual side-effects and an absence of problems when discontinuing it, with few side-effetcs and improved sleep without daytime drowsiness.
But I have not seen enough good research information about its effectiveness and side-effects to consider recommending it. Wise and experienced shrinks don't rush to prescribe the very newest available drug, in part because of the sort of issue you ask about --- until it has been used for some time and far more studies conducted, we don't know how it interactswith other drugs and substances, and what all its possible side-effects might be. SO I don't know whether it has been recognized as having the sort of side-efect you describe when combined with alcohol. Until this is clear, I would simply avoid alcohol, and have your depression properly treated according to your own doc's advice
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