Our expert says:
Presumably this is how she chooses to live. Its not compulsory to "have a life outside work", and some folks choose to work hard, and to rest at home. That she is apparently growing distant from her mother and sisters, and the other aspects you describe, does indeed sound as though she may have become depressed, and it would be a good idea if she could be persuaded to have a checkup at least with a GP and preferably with a psychiatrist, to assess whether she has a degree of depression which could usefully be treated with medication and counselling. If she is depressed, she could be feeling very much more cheerful and happy if she received proper treatment. Depression is common, and often arises for no recognizable reason within the person's life, often for entirely chemical reasons.
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