29 January 2013

The science behind satiety

New research from the University of British Columbia is shedding light on why enticing pictures of food affect us less when we’re full.


New research from the University of British Columbia is shedding light on why enticing pictures of food affect us less when we’re full.

“We’ve known that insulin plays a role in telling us we’re satiated after eating, but the mechanism by which this happens is unclear,” says Stephanie Borgland, an assistant professor in UBC’s Dept. of Anesthesiology, Pharmacology and Therapeutics and the study’s senior author.

How the study was done

In the new study published online this week in Nature Neuroscience, Borgland and colleagues found that insulin – prompted by a sweetened, high-fat meal – affects the ventral tegmental area (VTA) of the brain, which is responsible for reward-seeking behaviour. When insulin was applied to the VTA in mice, they no longer gravitated towards environments where food had been offered.

“Insulin dulls the synapses in this region of the brain and decreases our interest in seeking out food,” says Borgland, “which in turn causes us to pay less attention to food-related cues.”

Factors of the obesity epidemic

“There has been a lot of discussion around the environmental factors of the obesity epidemic,” Borgland adds, pointing to fast food advertising bans in Quebec, Norway, the UK, Greece and Sweden. “This study helps explain why pictures or other cues of food affect us less when we’re satiated – and may help inform strategies to reduce environmental triggers of overeating.”

The VTA has also been shown to be associated with addictive behaviours, including illicit drug use. Borgland says better understanding of the mechanism in this region of the brain could, in the long run, inform diagnosis and treatment.

(EurekAlert, January 2013)

Read more: 

Working out cuts appetite

Exercise may cut motivation for food

Pleasure eating may stimulate overeating


Read Health24’s Comments Policy

Comment on this story
Comments have been closed for this article.

Live healthier

Not loosing the weight? »

Your quick guide to Banting Banting for health? Banting vs Heart Foundation Diet – which is cheaper?

8 non-food reasons why your Banting weight loss has stalled

You're religiously sticking to your low-carb programme, but the scales aren’t moving. An extract from The Banting Solution looks at reasons why this could happen.

The struggle is real »

5 things to know before taking an antihistamine How to cope with seasonal allergies

15 tips for students with allergies

For university students, moving out of home can be daunting at the best of times but for those with severe allergies or asthma, it may feel close to impossible.