Updated 12 November 2013

Supplements may not guard against disease

According to a US government-backed panel there is little evidence that vitamin and mineral supplements protect people from cancer and heart problems.


There is little evidence that vitamin and mineral supplements protect people from cancer and heart problems, according to a new analysis. Based on those findings, a US government-backed panel issued draft recommendations that echo its previous conclusion: it cannot recommend for or against taking vitamins and minerals to prevent those conditions.

"At this point in time the science is not sufficient for us to estimate how much benefit or harm there is from taking vitamin or multivitamin supplements to prevent cancer or heart disease," Dr Michael LeFevre said.

LeFevre is co-vice chair of the US Preventive Services Task Force (USPSTF), which issues recommendations to help guide doctors and health systems. The USPSTF sponsored the new analysis.

The panel's draft statement also says neither beta-carotene nor vitamin E should be taken to prevent heart disease or cancer. Previously, beta-carotene was found to further increase the risk of lung cancer among people who are already at an increased risk.

Shared risk factors

Approximately 600 000 people die of heart disease in the US every year, according to the Centres for Disease Control and Prevention. Another 580 000 die of cancer, the American Cancer Society says.

Cancer and heart disease share a number of risk factors including inflammation, researchers wrote in the Annals of Internal Medicine. Animal and lab studies have suggested supplements may guard against some of those risk factors.

It's estimated that Americans spend about $12 billion each year on supplements. For the new analysis, Dr Stephen Fortmann and his colleagues from the Kaiser Permanente Centre for Health Research in Portland, Oregon, analysed studies that examined vitamin and mineral use to prevent cancer and heart disease.

After searching online medical research databases for studies published between January 2005 and January 2013, the researchers included data from 26 studies. Those studies examined the effects of multivitamins or specific vitamins and minerals taken together or alone.

The studies included anywhere from 128 to over 72 000 participants with average ages between 22 and 77. The average age for most studies was greater than 50, however. Participants were not taking supplements for any known nutritional deficiencies, such as low vitamin D levels.

The researchers found there was no difference in deaths between people taking multivitamins and people taking placebo pills or nothing. Also, there was no effect of multivitamins on fatal or non-fatal heart disease. Two trials did show a small reduction in new cancers over a 10-year period, but only in men.

Few quality studies

Fortmann and his colleagues concluded there is no consistent evidence that supplements – multivitamins or otherwise – affect the risk of heart disease, cancer or death among adults. That, they write, is consistent with earlier findings.

But they caution that there are few quality studies on supplements other than vitamin E and beta-carotene. After reviewing six trials on each, the researchers found vitamin E did not have any benefits. Beta-carotene increased the risk of lung cancer among smokers. "The main message is that there's not much evidence of a long term health benefit to taking most of the vitamins that people are taking," Fortmann told Reuters Health.

"But one has to qualify that comment, because we only looked at evidence through heart disease, cancer and deaths and it's hard to show an effect on those things."

Steve Mister, president and CEO of the Council for Responsible Nutrition (CRN) said most people don't take vitamins or minerals to protect against heart disease or cancer. "We have both government data and our own consumer study that we do every year," Mister said.

"Primarily, they take these vitamins or multivitamins because they know they're not eating the diet that they should... They help to fill in those gaps." CRN is a Washington, DC-based trade group that represents dietary supplement manufacturers and ingredient suppliers.

"We tell consumers to talk with a healthcare provider and recognise that a multivitamin is part of a healthy lifestyle," Mister told Reuters Health. "It's not a silver bullet that's going to save you from all the things that you do."

Supplements no excuse for a poor diet

Fortmann emphasized that message and said people shouldn't take supplements as an excuse for having a poor diet. "If you're taking a vitamin, you shouldn't be too confident that it's preventing any heart disease or cancer," he said. LeFevre, who is also a professor at the University of Missouri in Columbia, said the findings don't mean nutrition doesn't matter.

"Good nutrition is important and probably important for heart disease and cancer," he told Reuters Health. LeFevre added that the new statement also does not affect the panel's recommendation that older adults who are at high risk of falls should have physical therapy and take vitamin D supplements to reduce their chance of injury.


Read Health24’s Comments Policy

Comment on this story
Comments have been closed for this article.

Live healthier

Exercise benefits for seniors »

Working out in the concrete jungle Even a little exercise may help prevent dementia Here’s an unexpected way to boost your memory: running

Seniors who exercise recover more quickly from injury or illness

When sedentary older adults got into an exercise routine, it curbed their risk of suffering a disabling injury or illness and helped them recover if anything did happen to them.